Metallic profile of whole blood and plasma in a series of 106 healthy volunteers.
Identifieur interne : 000464 ( Main/Exploration ); précédent : 000463; suivant : 000465Metallic profile of whole blood and plasma in a series of 106 healthy volunteers.
Auteurs : Alexandre Cesbron [France] ; Elodie Saussereau ; Loïc Mahieu ; Isabelle Couland ; Michel Guerbet ; Jean-Pierre GoulléSource :
- Journal of analytical toxicology [ 1945-2403 ] ; 2013.
English descriptors
- KwdEn :
- Adult, Aging (metabolism), Blood Chemical Analysis (methods), Dental Amalgam (chemistry), Female, Humans, Indicators and Reagents, Limit of Detection, Longitudinal Studies, Male, Mass Spectrometry, Mercury (blood), Mercury Radioisotopes (blood), Metals (blood), Middle Aged, Plasma (chemistry), Quality Control, Sex Characteristics, Spectrophotometry, Ultraviolet, Tobacco, Young Adult.
- MESH :
- chemical , blood : Mercury, Mercury Radioisotopes, Metals.
- chemical , chemistry : Dental Amalgam.
- chemistry : Plasma.
- metabolism : Aging.
- methods : Blood Chemical Analysis.
- Adult, Female, Humans, Indicators and Reagents, Limit of Detection, Longitudinal Studies, Male, Mass Spectrometry, Middle Aged, Quality Control, Sex Characteristics, Spectrophotometry, Ultraviolet, Tobacco, Young Adult.
Abstract
In 2003, we simultaneously quantified 27 metals by inductively coupled plasma-mass spectrometry (ICP-MS) in the whole blood, plasma and urine of 100 healthy volunteers. We again determined the metallic profile in whole blood and plasma during 2012. ICP-MS validated multielementary method was performed for metals in whole blood and plasma. Whole blood vanadium and chromium were quantified using ICP-MS collision cell technology. The aims of the study were to compare and assess any changes in this profile, particularly due to the environment. Healthy male/female staff volunteers (n = 106) with no professional exposure to metals, or medication containing lithium, strontium; or food supplements with trace elements and vitamins and with no metal prosthesis were included. Tobacco consumption and the number of dental amalgams were recorded. Our results demonstrated a blood lead level that had drastically decreased, i.e. reduced by half, during this period (12.5 versus 26.3 µg/L, P < 0.0001). Known differences were observed between males and females for copper and zinc; cadmium and lead were higher in smokers. Median plasmatic mercury, a specific test for dental amalgam exposure, did not significantly increase (0.38 versus 0.28 µg/L, P = 0.11). The ICP-MS metallic profile is a very practical concept that is useful for clinical, forensic and environmental toxicology, including industrial hygiene monitoring.
DOI: 10.1093/jat/bkt046
PubMed: 23794607
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Metallic profile of whole blood and plasma in a series of 106 healthy volunteers.</title><author><name sortKey="Cesbron, Alexandre" sort="Cesbron, Alexandre" uniqKey="Cesbron A" first="Alexandre" last="Cesbron">Alexandre Cesbron</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Pharmacocinétique et de Toxicologie Cliniques, Groupe Hospitalier du Havre, Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacocinétique et de Toxicologie Cliniques, Groupe Hospitalier du Havre, Le Havre</wicri:regionArea><placeName><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Saussereau, Elodie" sort="Saussereau, Elodie" uniqKey="Saussereau E" first="Elodie" last="Saussereau">Elodie Saussereau</name></author><author><name sortKey="Mahieu, Loic" sort="Mahieu, Loic" uniqKey="Mahieu L" first="Loïc" last="Mahieu">Loïc Mahieu</name></author><author><name sortKey="Couland, Isabelle" sort="Couland, Isabelle" uniqKey="Couland I" first="Isabelle" last="Couland">Isabelle Couland</name></author><author><name sortKey="Guerbet, Michel" sort="Guerbet, Michel" uniqKey="Guerbet M" first="Michel" last="Guerbet">Michel Guerbet</name></author><author><name sortKey="Goulle, Jean Pierre" sort="Goulle, Jean Pierre" uniqKey="Goulle J" first="Jean-Pierre" last="Goullé">Jean-Pierre Goullé</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23794607</idno><idno type="pmid">23794607</idno><idno type="doi">10.1093/jat/bkt046</idno><idno type="wicri:Area/PubMed/Corpus">000155</idno><idno type="wicri:Area/PubMed/Curation">000155</idno><idno type="wicri:Area/PubMed/Checkpoint">000155</idno><idno type="wicri:Area/Ncbi/Merge">000360</idno><idno type="wicri:Area/Ncbi/Curation">000360</idno><idno 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sort="Saussereau, Elodie" uniqKey="Saussereau E" first="Elodie" last="Saussereau">Elodie Saussereau</name></author><author><name sortKey="Mahieu, Loic" sort="Mahieu, Loic" uniqKey="Mahieu L" first="Loïc" last="Mahieu">Loïc Mahieu</name></author><author><name sortKey="Couland, Isabelle" sort="Couland, Isabelle" uniqKey="Couland I" first="Isabelle" last="Couland">Isabelle Couland</name></author><author><name sortKey="Guerbet, Michel" sort="Guerbet, Michel" uniqKey="Guerbet M" first="Michel" last="Guerbet">Michel Guerbet</name></author><author><name sortKey="Goulle, Jean Pierre" sort="Goulle, Jean Pierre" uniqKey="Goulle J" first="Jean-Pierre" last="Goullé">Jean-Pierre Goullé</name></author></analytic><series><title level="j">Journal of analytical toxicology</title><idno type="eISSN">1945-2403</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aging (metabolism)</term><term>Blood Chemical Analysis (methods)</term><term>Dental Amalgam (chemistry)</term><term>Female</term><term>Humans</term><term>Indicators and Reagents</term><term>Limit of Detection</term><term>Longitudinal Studies</term><term>Male</term><term>Mass Spectrometry</term><term>Mercury (blood)</term><term>Mercury Radioisotopes (blood)</term><term>Metals (blood)</term><term>Middle Aged</term><term>Plasma (chemistry)</term><term>Quality Control</term><term>Sex Characteristics</term><term>Spectrophotometry, Ultraviolet</term><term>Tobacco</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Mercury</term><term>Mercury Radioisotopes</term><term>Metals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Dental Amalgam</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plasma</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Aging</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Blood Chemical Analysis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Indicators and Reagents</term><term>Limit of Detection</term><term>Longitudinal Studies</term><term>Male</term><term>Mass Spectrometry</term><term>Middle Aged</term><term>Quality Control</term><term>Sex Characteristics</term><term>Spectrophotometry, Ultraviolet</term><term>Tobacco</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 2003, we simultaneously quantified 27 metals by inductively coupled plasma-mass spectrometry (ICP-MS) in the whole blood, plasma and urine of 100 healthy volunteers. We again determined the metallic profile in whole blood and plasma during 2012. ICP-MS validated multielementary method was performed for metals in whole blood and plasma. Whole blood vanadium and chromium were quantified using ICP-MS collision cell technology. The aims of the study were to compare and assess any changes in this profile, particularly due to the environment. Healthy male/female staff volunteers (n = 106) with no professional exposure to metals, or medication containing lithium, strontium; or food supplements with trace elements and vitamins and with no metal prosthesis were included. Tobacco consumption and the number of dental amalgams were recorded. Our results demonstrated a blood lead level that had drastically decreased, i.e. reduced by half, during this period (12.5 versus 26.3 µg/L, P < 0.0001). Known differences were observed between males and females for copper and zinc; cadmium and lead were higher in smokers. Median plasmatic mercury, a specific test for dental amalgam exposure, did not significantly increase (0.38 versus 0.28 µg/L, P = 0.11). The ICP-MS metallic profile is a very practical concept that is useful for clinical, forensic and environmental toxicology, including industrial hygiene monitoring.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Le Havre</li></settlement></list><tree><noCountry><name sortKey="Couland, Isabelle" sort="Couland, Isabelle" uniqKey="Couland I" first="Isabelle" last="Couland">Isabelle Couland</name><name sortKey="Goulle, Jean Pierre" sort="Goulle, Jean Pierre" uniqKey="Goulle J" first="Jean-Pierre" last="Goullé">Jean-Pierre Goullé</name><name sortKey="Guerbet, Michel" sort="Guerbet, Michel" uniqKey="Guerbet M" first="Michel" last="Guerbet">Michel Guerbet</name><name sortKey="Mahieu, Loic" sort="Mahieu, Loic" uniqKey="Mahieu L" first="Loïc" last="Mahieu">Loïc Mahieu</name><name sortKey="Saussereau, Elodie" sort="Saussereau, Elodie" uniqKey="Saussereau E" first="Elodie" last="Saussereau">Elodie Saussereau</name></noCountry><country name="France"><noRegion><name sortKey="Cesbron, Alexandre" sort="Cesbron, Alexandre" uniqKey="Cesbron A" first="Alexandre" last="Cesbron">Alexandre Cesbron</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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